Individually, multivitamins, zinc, polyphenols, omega-3 fatty acids, and probiotics are shown to support brain function either through the gut–brain axis or through antioxidant functions [6,7,8,9,10]. However, the effect of various combinations of these nutrients on cognition and spatial memory remains unexplored. Knowing the most effective combination of antioxidants and/or probiotics is important, as regular ingestion of all nutraceuticals may not be practical. Finding the combination of nutrients that best enhances cognitive performance is crucial to developing strategies for improved learning and cognition in humans.